Green synthesised Catharanthus roseus-mediated iron oxide nanoparticles demonstrates enhanced antibacterial, antioxidant, and anti-diabetic properties
The therapeutic possibility of Catharanthus roseus ethanolic extract of leaves (CELEs) was related with that of C. roseus mediated green synthesized iron oxide nanoparticles (CELFeNPs) for its antibacterial, antioxidant, as well as anti-diabetic activities. The bioactive components in CELE were assessed by gas chromatography-mass spectrometry to prepare Fe2O3 nanoparticles (CELFeNPs) utilizing the phytoreducing method of green synthesis. Fourier transform-infrared spectroscopy analysis was performed to analyze the capping of nanoparticles by phytochemicals, and the crystalline nature was validated by X-ray diffraction analysis. Comparative antioxidant activity was assayed by 2,2-Diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power assay, antidiabetic effect was evaluated by alpha-amylase inhibitory activity, and antibacterial activity was assessed. CELFeNPs showed enhanced antioxidant activity than CELE. The antibacterial efficacy of CELFeNPs improved with increased nanoparticle concentration. The alpha-amylase inhibitory activity of CELFeNPs was higher than CELE for concentrations ranging from 20 to 100μg/ ml. Green synthesized CELFeNPs demonstrated superior antioxidant, antibacterial, and anti-diabetic activity when compared with CELE. The results from the current research indicate that the Fe2O3 nanoparticles produced by green synthesis utilizing C. roseus ethanolic leaf extract have greater efficacy than the C. roseus ethanolic leaf extract and could be used as a therapeutic agent.
Akkara PJ, Martin SA, Thiagarajulu N, Bisht AB, Mishal A, Mathew CM. Green synthesised Catharanthus roseus-mediated iron oxide nanoparticles demonstrates enhanced antibacterial, antioxidant, and anti-diabetic properties. J Appl Biol Biotech. 2025. http://doi.org/10.7324/JABB.2025.220729
1. Vetrimani A, Geetha K, Jemima EA, Arulnathan N, Kim HS, Kathalingam A. Effect of the green synthesis of CuO plate-like nanoparticles on their photodegradation and antibacterial activities. Phys Chem Chem Phys 2022;24(47):28923–33; doi: http://dx.doi.org/10.1039/D2CP03531F
2. Arsiya F, Sayadi MH, Sobhani S. Green synthesis of palladium nanoparticles using Chlorella vulgaris. Mater Lett 2016;186:113–5; doi: https://doi.org/10.1016/j.matlet.2016.09.101
3. Kumar A, Singhal A. Synthesis of colloidal β-Fe2O3 nanostructures-influence of addition of Co2+ on their morphology and magnetic behavior. J Nanotech 2007;18:475703; doi: https://doi.org/10.1088/0957-4484/18/47/475703
4. Hasany SF, Ahmed I, Rajan J, Rehman A. Systematic review of the preparation techniques of iron oxide magnetic nanoparticles. J Nanosci Nanotechnol 2013;2(6):148–58; doi: https://doi.org/10.5923/j.nn.20120206.01
5. Laurent S, Forge D, Port M, Roch A, Robic C, Elst LV, et al. Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem Rev 2010;110:2574; doi: https://doi.org/10.1021/cr068445e
6. Kamath V, Chandra P, Jeppu GP. Comparative study of using five different leaf extracts in the green synthesis of iron oxide nanoparticles for removal of arsenic from water. Int J Phytoremediation 2020;22(12):1278–94; doi: https://doi.org/10.1080/15226514.2020. 1765139
7. Reddy NJ, Vali DN, Rani M, Rani SS. Evaluation of antioxidant, antibacterial and cytotoxic effects of green synthesized silver nanoparticles by Piper longum fruit. Mater Sci Eng C Mater Biol Appl 2014;34:115–22; doi: https://doi.org/10.1016/j.msec.2013.08.039
8. Pham HNT, Sakoff JA, Vuong QV, Bowyer MC, Scarlett CJ. Screening phytochemical content, antioxidant, antimicrobial and cytotoxic activities of Catharanthus roseus (L.) G. Don stem extract and its fractions. Biocatal Agric Biotechnol 2018;16:405–11; doi: https://doi.org/10.1016/j.bcab.2018.09.005
9. Nejat N, Valdiani A, Cahill D, Tan YH, Maziah M, Abiri R. Ornamental exterior versus therapeutic interior of Madagascar periwinkle (Catharanthus roseus): the two faces of a versatile herb. Sci World J 2015;2015:982412; doi: https://doi.org/10.1155/2015/982412
10. Hano C, Abbasi BH. Plant-based green synthesis of nanoparticles: production, characterization and applications. Biomolecules 2021;12(1):31; doi: https://doi.org/10.3390/biom12010031
11. Kabesh K, Senthilkumar P, Ragunathan R, Kumar RR. Phytochemical analysis of Catharanthus roseus plant extract and its antimicrobial activity. Int J Pure App Biosci 2015;3(2):162–72.
12. Pham HNT, Sakoff JA, Vuong QV, Bowyer MC, Scarlett CJ. Phytochemicals derived from Catharanthus roseus and their health benefits. Technologies 2020;8(4):80; doi: https://doi.org/10.3390/technologies8040080
13. Gomathi D, Kalaiselvi M, Ravikumar G, Devaki K, Uma C. GC-MS analysis of bioactive compounds from the whole plant ethanolic extract of Evolvulusalsinoides (L.) L. J Food Sci Technol 2015;52(2):1212–7; doi: https://doi.org/10.1007/s13197- 013-1105-9
14. Nahari MH, Al Ali A, Asiri A, Mahnashi MH, Shaikh IA, Shettar AK. Green synthesis and characterization of iron nanoparticles synthesized from aqueous leaf extract of Vitex leucoxylon and its biomedical applications. Nanomaterials (Basel, Switzerland.) 2022;12(14):2404; doi: https://doi.org/10.3390/nano12142404
15. Ali A, Zafar H, Zia M, Haq IU, Phull AR, Ali JS, et al. Synthesis, characterization, applications, and challenges of iron oxide nanoparticles. Nanotechnol Sci Appl 2016;9:49–67; doi: https://doi.org/10.2147/NSA.S99986
16. Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem 1996;239(1):70–6; doi: https://doi.org/10.1006/abio.1996.0292
17. Felt DR, Larson SL, Valente EJ. UV-VIS spectroscopy of 2,4,6-trinitrotoluene-hydroxide reaction. Chemosphere 2002;49(3):287–95; doi: https://doi.org/10.1016/s0045-6535(02)00283-7
18. Krysa M, Szyma?ska-Chargot M, Zdunek A. FT-IR and FT-Raman fingerprints of flavonoids—a review. Food Chem 2022;393:133430; doi: https://doi.org/10.1016/j.foodchem.2022.133430
19. Rahuman HBH, Dhandapani R, Narayanan S, Palanivel V, Paramasivam R, Subbarayalu R, et al. Medicinal plants mediated the green synthesis of silver nanoparticles and their biomedical applications. IET Nanobiotechnol 2022;16(4):115–44; doi: https://doi.org/10.1049/nbt2.12078
20. Desmarchelier C, Bermudez MJN, Coussio J, Ciccia G, Boveris A. Antioxidant and prooxidant activities in aqueous extract of Argentine plants. Int J Pharmacogn 1997;35(2):116–20; doi: http://dx.doi.org/10.1076/phbi.35.2.116.13282
21. Munteanu IG, Apetrei C. Analytical methods used in determining antioxidant activity: a review. Int J Mol Sci 2021;22(7):3380; doi: https://doi.org/10.3390/ijms22073380
22. Dash A, Ahmed MT, Selvaraj R. Mesoporous magnetite nanoparticles synthesis using the Peltophorum pterocarpum pod extract, their antibacterial efficacy against pathogens and ability to remove a pollutant dye. J Mol Struct 2019;1178:268–73; doi: https://doi.org/10.1016/j.molstruc.2018.10.042
23. Arora DS, Kaur J. Antimicrobial activity of spices. Int J Antimicrob Agents 1999;12(3):257–62; doi: https://doi.org/10.1016/s0924- 8579(99)00074-6
24. Wickramaratne MN, Punchihewa JC, Wickramaratne DB. In-vitro alpha amylase inhibitory activity of the leaf extracts of Adenanthera pavonina. BMC Compl Alt Med 2016;16(1):466; doi: https://doi.org/10.1186/s12906-016-1452-y
25. Lesiak B, Rangam N, Jiricek P, Gordeev I, Tóth J, Kövér L, et al. Surface study of Fe3O4 nanoparticles functionalized with biocompatible adsorbed molecules. Front Chem 2019;7:642; doi: https://doi.org/10.3389/fchem.2019.00642
26. Sajid M, P?otka-Wasylka J. Nanoparticles: synthesis, characteristics, and applications in analytical and other sciences. Microchem J 2020;154:104623; doi: http://dx.doi.org/10.1016/j.microc.2020.104623
27. Jeevanandam J, Ling JKU, Barhoum A, Chan YS, Danquah MK. Bionanomaterials: definitions, sources, types, properties, toxicity, and regulations. Fund Bionanomat 2022;4(5):1–29; doi: https://doi.org/10.1016/B978-0-12-824147-9.00001-7
28. Kanthal LK, Dey A, Satyavathi K, Bhojaraju P. GC-MS analysis of bio-active compounds in methanolic extract of Lactucaruncinata DC. Pharmacogn Res 2014;6(1):58–61; doi: https://doi.org/10.4103/0974-8490.122919
29. Olivia NU, Goodness UC, Obinna OM. Phytochemical profiling and GC-MS analysis of aqueous methanol fraction of Hibiscus asper leaves. Futur J Pharm Sci 2021;7:59; doi: https://doi.org/10.1186/s43094-021-00208-4
30. De Pinho PG, Gonçalves RF, Valentão P, Pereira DM, Seabra RM, Andrade PB, et al. Volatile composition of Catharanthus roseus (L.) G. Don using solid-phase microextraction and gas chromatography/ mass spectrometry. J Pharm Biomed Anal 2009;49(3):674–85; doi: https://doi.org/10.1016/j.jpba.2008.12.032
31. Kennedy GM, Min MY, Fitzgerald JF, Nguyen MT, Schultz SL, Crum MT, et al. Inactivation of the bacterial pathogens Staphylococcus pseudintermedius and Acinetobacter baumannii by butanoic acid. J Appl Microbiol 2019;126(3):752–63; doi: https://doi.org/10.1111/jam.14180
32. Moothoo DN, Canan B, Field RA, Naismith JH. Man alpha1-2 Man alpha-OMe-concanavalin A complex reveals a balance of forces involved in carbohydrate recognition. Glycobiology 1999;9(6):539– 45; doi: https://doi.org/10.1093/glycob/9.6.539
33. Fenili D, Brown M, Rappaport R, McLaurin J. Properties of scyllo-inositol as a therapeutic treatment of AD-like pathology. J Mol Med (Berl) 2007;85(6):603–11; doi: https://doi.org/10.1007/s00109-007-0156-7
34. Fu W, Zhao Y, Xie J, Yang Y, Xiao P. Identification of anti-hepatic fibrosis components in Periplaneta americana based on spectrum-effect relationship and chemical component separation. Biomed Chromatogr 2022;36(3):e5286; doi: https://doi.org/10.1002/bmc.5286
35. Bhati M. Biogenic synthesis of metallic nanoparticles: principles and applications. Mater Today Proc 2023;81:882–7; doi: https://doi.org/10.1016/j.matpr.2021.04.272
36. Fousteris MA, Koutsourea AI, Arsenou ES, Papageorgiou A, Mourelato D, Nikolaropoulos SS. Antileukemic and cytogenetic effects of modified and non-modified esteric steroidal derivatives of 4-methyl-3-bis(2-chloroethyl)amino benzoic acid (4-Me-CABA). Anticancer Res 2002;22(4):2293–9.
37. Wei Y, Fang Z, Zheng L, Tan L, Tsang EP. Green synthesis of Fe nanoparticles using Citrus maxima peels aqueous extracts. Mater Lett 2016;185:384–6; doi: http://dx.doi.org/10.1016/j.matlet.2016.09.029
38. Vahini M, Rakesh SS, Subashini R, Loganathan S, Prakash DG. In vitro biological assessment of green synthesized iron oxide nanoparticles using Anastatica hierochuntica (Rose of Jericho). Biomass Conv Bioref 2023;14(16):1–11; doi: http://dx.doi.org/10.1007/s13399-023-04018-x
39. Kiwumulo HF, Muwonge H, Ibingira C, Lubwama M, Kirabira JB, Ssekitoleko RT. Green synthesis and characterization of iron-oxide nanoparticles using Moringa oleifera: a potential protocol for use in low and middle income countries. BMC Res Notes 2022;15(1):1–8; doi: https://doi.org/10.1186/s13104-022-06039-7
40. Ahmmad B, Leonard K, Islam MS, Kurawaki J, Muruganandham M, Ohkubo T, et al. Green synthesis of mesoporous hematite (α-Fe2O3) nanoparticles and their photocatalytic activity. Adv Powder Technol 2013;24(1):160–67; doi:
41. Hastak V, Bandi S, Kashyap S, Singh S, Luqman S, Lodhe M, et al. Antioxidant efficacy of chitosan/graphene functionalized superparamagnetic iron oxide nanoparticles. J Mater Sci Mater Med 2018;29(10):154; doi: https://doi.org/10.1007/s10856-018-6163-0
42. Nisar A, Mamat AS, Hatim MI, Aslam MS, Ahmad MS. Antioxidant and total phenolic content of Catharanthus roseus using deep eutectic solvent. Rec Adv Biol Med 2017;03:1283; doi: http://dx.doi.org/10.18639/RABM.2017.03.355635
43. Gupta M, Tomar RS, Kaushik S, Mishra RK, Sharma D. Effective antimicrobial activity of green ZnO nanoparticles of Catharanthus roseus. Front Microbiol 2018;9:2030; doi:
44. Senthil M, Ramesh C. Biogenic synthesis of Fe3O4 nanoparticles using Tridax procumbens leaf extract and its antibacterial activity on Pseudomonas aeruginosa. Dig J Nanomater Biostructures 2012;7(4):1655–60.
45. Senthilkumar S, Siva E, Rajendran A. Characterization and antimicrobial activity of ECO-friendly biosynthesis of silver nanoparticles using an aqueous leaf extract of Catharanthus roseus. IOSR J App Phys 2017;01(01):71–5.
46. Bobe G, Zhang Z, Kopp R, Garzotto M, Shannon J, Takata Y. Phytol and its metabolites phytanic and pristanic acids for risk of cancer: current evidence and future directions. Eur J Cancer Prev 2020;29(2):191– 200; doi: https://doi.org/10.1097/CEJ.0000000000000534
47. Lu Z, Yu D, Nie F, Wang Y, Chong Y. Iron nanoparticles open up new directions for promoting healing in chronic wounds in the context of bacterial infection. Pharmaceutics 2023;15(9):2327; doi: https://doi.org/10.3390/pharmaceutics15092327
48. Akkara PJ, Martin SA, Tomy AM, Menon AS, Takri G. Methanolic leaf extract of Catharanthus roseus reveals wound healing activity on mouse fibroblast L92 cell lines. Med Plants Int J Phytomed 2023;15(03):587–94.
49. Rasineni K, Bellamkonda R, Singareddy SR, Desireddy S. Antihyperglycemic activity of Catharanthus roseus leaf powder in streptozotocin-induced diabetic rats. Pharmacogn Res 2010;2(3):195–201; doi: https://doi.org/10.4103/0974-8490.65523
50. Shabbir MA, Naveed M, ur Rehman S, ul Ain N, Aziz T, Alharbi M, et al. Synthesis of iron oxide nanoparticles from Madhuca indica plant extract and assessment of their cytotoxic, antioxidant, anti-inflammatory, and anti-diabetic properties via different nanoinformatics approaches. ACS Omega 2023;8(37):33358–66; doi: https://doi.org/10.1021/acsomega.3c02744
51. Yadwade R, Kirtiwar S, Ankamwar B. A review on green synthesis and applications of iron oxide nanoparticles. J Nanosci Nanotechnol 2021;21(12):5812–34; doi: https://doi.org/10.1166/jnn.2021.19285
52. Goboza M, Meyer M, Aboua YG, Oguntibeju OO. In vitro antidiabetic and antioxidant effects of different extracts of Catharanthus roseus and its indole alkaloid, vindoline. Molecules 2020;25(23):5546; doi: https://doi.org/10.3390/molecules25235546
53. Kumar S, Narwal S, Kumar V, Prakash O. α-Glucosidase inhibitors from plants: a natural approach to treat diabetes. Pharmacogn Rev 2011;5(9):9; doi: https://doi.org/10.4103/0973-7847.79096
54. Khadayat K, Marasini BP, Gautam H, Ghaju S, Parajuli N. Evaluation of the alpha-amylase inhibitory activity of Nepalese medicinal plants used in the treatment of diabetes mellitus. Clin Phytosci 2020;6:34; doi: https://doi.org/10.1186/s40816-020- 00179-8
Year
Month
The physicochemical and biological properties of novel silver nanoparticles synthesized by the extract of Holigarna ferruginea
Kumbar Mudakappa Manjunath, Y. L. KrishnamurthySolid-state fermentation of pigment producing endophytic fungus Fusarium solani from Madiwala lake and its toxicity studies
Bhoomika Prakash Poornamath, Suma Sarojini, Saranya Jayaram, Soma Biswas, Anand Kaloor, Mridul UmeshIn vitro Antimicrobial Comparison of Taif and Egyptian Pomegranate Peels and Seeds Extracts
Ahmed Gaber , Mohamed M. Hassan , El-Dessoky S. Dessoky , Attia O. AttiaPotential use as a bio-preservative from lupin protein hydrolysate generated by alcalase in food system
Ali Osman, Ghada M. El-Araby, Hefnawy TahaAntimicrobial Activity Screening of Marine Bacteria Isolated from the Machilipatnam Sea Coast of Andhra Pradesh, India
K. Bala Chandra, V. Umamaheswara Rao, Subhaswaraj Pattnaik, Siddhardha BusiAntimicrobial effect of nanofluid including Zinc oxide (ZnO) nanoparticles and Mentha pulegium essential oil
Mona Jahanpanahi, Ali Mohamadi SaniInducible Antimicrobial Compounds (Halal) Production in Honey Bee Larvae (Apis mellifera) from Rumaida, Taif by injecting of various dead Microorganisms extracts
Abd-ElAziem Farouk, N. Thoufeek Ahamed, Othman AlZahrani, Akram Alghamdi, AbdulAziz BahobailBioactive potential of Diadema sp. from the South East Coast of Mauritius
Lisa Karen Yee Chin Youne Ah Shee Tee, Daneshwar Puchooa, Vishwakalyan BhoyrooApplication of Mentha suaveolens essential oil as an antimicrobial agent in fresh turkey sausages
Abdelaziz Ed-Dra, Fouzia Rhazi Filai, Mohamed Bou-Idra, Badr Zekkori, Aziz Bouymajane, Najia Moukrad, Faouzia Benhallam, Amar BentayebEffect of growth hormones in induction of callus, antioxidants, and antibacterial activity in Nerium odorum
Avinash Prakasha, S UmeshaBiosynthesis, characterization and antibacterial activity of silver nanoparticles from Aspergillus awamori
Vishwanatha T, Keshavamurthy M, Mallappa M, Murugendrappa MV , Nadaf YF, Siddalingeshwara KG, Dhulappa AA study of endophytic fungi Neofusicoccum ribis from Gandaria (Bouea macrophylla Griffith) as enzyme inhibitor, antibacterial, and antioxidant
Trisanti Anindyawati, PraptiwiDetermination of phytochemical, antioxidant, antimicrobial, and protein binding qualities of hydroethanolic extract of Celastrus paniculatus
Vijay Kumar¥, Simranjeet Singh¥, Arjun Singh¥, Amit Kumar Dixit¥, Bhavana Shrivastava, Sapna Avinash Kondalkar, Joginder Singh, Ravindra Singh, Gurpreet Kaur Sidhu, Rajesh Partap Singh, Varanasi Subhose, Om PrakashAntibacterial activity of an endophytic fungus Lasiodiplodia pseudotheobromae IBRL OS-64 residing in leaves of a medicinal herb, Ocimum sanctum Linn.
Taufiq M.M.J., Darah I.Antibacterial activity of leaf extract of Chromolaena odorata and the effect of its combination with some conventional antibiotics on Pseudomonas aeruginosa isolated from wounds
P. Odinakachukwu Omeke, J. Okechukwu Obi, N. A. Ibuchukwu Orabueze , Anthony Chibuogwu IkePhytochemical analysis, antimicrobial and antioxidant activities of Aidia borneensis leaf extracts
Zulhamizan Awang-Jamil, Aida Maryam Basri, Norhayati Ahmad, Hussein TahaResponse of green synthesized drug blended silver nanoparticles against periodontal disease triggering pathogenic microbiota
Neeraj Kumar Fuloria, Shivkanya Fuloria, Kok Yik Chia, Sundram Karupiah, Kathiresan SathasivamCharacterization of extracellular polymeric substance producing isolates from wastewaters and their antibacterial prospective
Anita Rani Santal,Nater Pal Singh,Tapan Kumar SinghaAnti-quorum sensing, antibacterial, antioxidant activities, and phytoconstituents analysis of medicinal plants used in Benin: Acacia macrostachya (Rchb. ex DC.)
Mounirou Tchatchedre, Abdou Madjid O. Amoussa, Ménonvè Atindehou, Aminata P. Nacoulma, Ambaliou Sanni, Martin kiendrebeogo, Latifou LagnikaApplication of guava leaves extract on jelly candy to inhibit Streptococcus mutans
Yuniwaty Halim, Raphael Dimas Tri Nugroho, Hardoko,, Ratna HandayaniIdentification and bioactivities of endophytic fungi from Lagenandra toxicaria Dalz. and Kaempferia rotunda L.
Praveen Krishnakumar, Mable Varghese, Maria Grace Joe, Asha Rajagopal, Leyon VargheseAntibacterial activity and hormetic response of silver nanoparticles synthesized using leaflet extract of wheat (Triticum aestivum) and rice (Oryza sativa) crop plants
Vikas Pahal, Pankaj Kumar, Parveen Kumar, Vinod KumarIn vitro evaluation of the antibacterial potential of flavonoid glycosides from Glinus oppositifolius (L.) Aug. DC.
K. Suresh Kannan, D. Kandavel, P. Rajalakshmi, P. MaheswariSilver nanoparticles decorated natural products doped polyaniline hybrid materials for biomedical applications
K. Satish, K. Sumangala Bhat, Y. S. Ravikumar, M. N. K. HarishNeutrophil gelatinase-associated lipocalin a proinflammatory polypeptide necessary for host cell survival in bacterial infection
Nichita Yadav Aare, Pawan Kumar Anoor, Swathi Raju M, N. Srinivas Naik, Sandeepta BurgulaExtraction of a novel bacteriocin from Lacticaseibacillus casei VITCM05 and its antibacterial activity against major food-borne pathogens
Jannatul Firdous Siddique, Mohanasrinivasan VaithilingamChemical profiling, in vitro antibacterial, and cytotoxic properties of Elytranthe parasitica (L.) Danser – A hemiparasitic Indian mistletoe
Keragodu Paramesh Sharath, Raja NaikaIn vitro antioxidant and antibacterial potential of biosynthesized yttrium oxide nanoparticles using floral extract of Illicium verum
Karthikeyan Kandasamy, Premkumar KumpatiChemical and antibacterial properties of chitosan derived from Mucor spp., Rhizopus. Oryzae and Hermetia illucens
Muhammad Yusuf Abduh,, Tri Ramadianti Shafitri,, Maryam Jamilah, Mochamad Firmansyah,, Robert ManurungProduction of antibacterial substance by immobilized cells of Geobacillus subterraneus Tm6Sp1 isolate of Mount Kamojang Crater, west java, against pathogenic bacteria
Candra Arumimaniyah, Ratu Safitri, Emma Rachmawati, Ani Melani Maskoen, Akeyla Tabina Tawangalun, Shinta AsarinaGreen synthetic photo-irradiated chitin-silver nanoparticles for antimicrobial applications
Navya Kumari Tenkayala,, Laxman Vamshi Krishna Kandala, Roopkumar Sangubotla, Rambabu Gundla, Subramani DevarajuEffects of abiotic and biotic stresses on antagonistic activities of symbiotic bacterial strains isolated from Adenosma bracteosum
Thanh-Dung Nguyen, Huu-Nghia Duong, Phu-Tho Nguyen,, Thuy-Trang Pham, Huu-Hiep Nguyen, Thi-Pha Nguyen, Huu-Thanh Nguyen,Bioactivity assessment of endophytic fungi associated with Centella asiatica and Murraya koengii
Archana Nath, Jyoti Pathak and SR JoshiAsparagus racemosus extract increases the life span in Drosophila melanogaster
K. V. Kiran Kumar, K. S. Prasanna, J. S. AshadeviComparative three way analysis of biochemical responses in cereal and millet crops under salinity stress
Ritika Bhatt, Prem Prakash Asopa, Santosh Sihag, Rakesh Sharma, Sumita Kachhwaha, S.L. KothariImpact of Phyllanthus amarus extract on antioxidant enzymes in Drosophila melanogaster
N. Manasa, J. S. AshadeviAlterations in antioxidant defense system in hepatic and renal tissues of rats following aspartame intake
Saeed A. AlwaleediTen different brewing methods of green tea: comparative antioxidant study
Naila Safdar, Amina Sarfaraz, Zehra Kazmi, Azra YasminMedicinal and Functional Values of Thyme (Thymus vulgaris L.) Herb
Eqbal M. A. Dauqan, Aminah AbdullahBuffalo (Bubalus bubilis) colostrum and milk fat globule membrane fractions are potent antioxidants
N. Brijesha, H. S. AparnaEffect of extraction solvents on phenolic contents and antioxidant capacities of Artocarpus chaplasha and Carissa carandas fruits from Bangladesh
Gouri Dhar, Sonam Akther, Afrin Sultana, Uchen May, Mohammed Moinul Islam, Mowri Dhali, Dwaipayan SikdarIn Vitro Antidiabetic and Anti-oxidant Activities of Methanol Extract of Tinospora Sinensis
Anindita Banerjee, Bithin Maji, Sandip Mukherjee, Kausik Chaudhuri, Tapan SealChemical composition, antioxidant and antimicrobial activities of the essential oil of Vetiveria nigritana (Benth.) Stapf roots from Burkina Faso
Zenabou Semde, Jean Koudou, Cheikna Zongo, Gilles Figueredo, Marius K. Somda, Leguet Ganou, Alfred S. TraoreCrosstalk of brassinosteroids with other phytohormones under various abiotic stresses
Farhan Ahmad, Ananya Singh, Aisha KamalIn vitro propagation by axillary shoot proliferation, assessment of antioxidant activity, and genetic fidelity of micropropagated Paederia foetida L.
Biswaranjan Behera, Priyajeet Sinha, Sushanto Gouda, Sakti K. Rath, Durga P. Barik, Padan K. Jena, Pratap C. Panda, Soumendra K. NaikAroclor 1254 induced oxidative stress and histopathological changes in mice liver
Jalpa Raja, Shweta Pathak, Rahul KunduEffect of Trema guineensis leaves (celtidaceae) on glucose-induced hypertension in Wistar rats
Balakiyém Kadissoli, P A Mouzou, T Pakoussi, K Eklu-Gadegbeku, A K Aklikokou, M GbeassorComparative chemical and biological investigations of three Saudi Astragalus species
Mohamed A. AshourPhytochemical analysis and antioxidant potential of Ocimum gratissimum Linn (Lamiaceae) commonly consumed in the Republic of Benin
Hinnoutondji Wilfrid Kpètèhoto, Abdou Madjid Olatoundé Amoussa, Roch Christian Johnson, Eustache Enock Meinsan Houéto , Franck Maurille Zinsou Mignanwandé, Hounnankpon Yédomonhan, Frédéric Loko, Honoré Bankolé, Latifou LagnikaPleurotus pulmonarius (Fr.) Quel. (Pleurotaceae): In vitro antioxidant evaluation and the isolation of a steroidal isoprenoid
Blessing Onyinye Okonkwo, Ozadheoghene Eriarie Afieroho, Emeka Daniel Ahanonu, Lambert Okwubie, Kio Anthony AboStudy of the changes in the growth, protein, and bioactive profile of Chlorella emersonii KJ725233 in response to sodium and ammonium nitrate
Sneha Sunil Sawant, Varsha Kelkar-ManeDetermination of phenolic content and antioxidant capacity of Launaea resedifolia from Algerian Sahara
Amina Bouguerra, Mohamed Hadjadj, Mesaouda Dekmouche, Zhour Rahmani, Houssine DendouguiInvestigation of morphological, phytochemical, and enzymatic characteristics of Anethum graveolens L. using selenium in combination with humic acid and fulvic acid
Parviz Samavatipour, Vahid Abdossi, Reza Salehi, Saeed Samavat,Alireza Ladan MoghadamA study on the salinity stress effects on the biochemical traits of seedlings and its relationship with resistance toward sensitive and tolerant flax genotypes
Yousef Alaei, Seyed Kamal Kazemitabar, Mohammad Zaefi Zadeh, Hamid Najafi Zarini, Gaffar KianiNyctanthes arbor-tristis: Comprehensive review on its pharmacological, antioxidant, and anticancer activities
Smita Parekh, Anjali SoniStudies on the mechanism of desiccation tolerance in the resurrection fern Adiantum raddianum
Tumkur Govindaraju Banupriya, Chandraiah Ramyashree, Devaraja Akash, Neeragunda Shivaraj Yathish, Ramasandra Govindarao SharthchandraAntioxidant and antihyperlipidemic effects of aqueous seed extract of Daucus carota L. in triton ×100-induced hyperlipidemic mice
Habibu Tijjani, Abubakar Mohammed, Sani Muktar, Saminu Musa, Yusuf Abubakar, Adegbenro Peter Adegunloye, Ahmed Adebayo Ishola, Enoch Banbilbwa Joel, Carrol Domkat Luka, Adamu Jibril AlhassanRole of glutathione reductase and catalase enzyme in antioxidant defense mechanism in controlling fluoride-induced oxidative stress
Komal Sharma, Mamta Choudhary, Khushbu VermaBiological activities and phytochemicals of Hyptis capitata grown in East Kalimantan, Indonesia
Irawan Wijaya Kusuma, Rahmini, Enos Tangke Arung, Arif Yudo Pramono, Erwin, SupomoMycelial biomass, antioxidant, and myco-actives of mycelia of abalone mushroom Pleurotus cystidiosus in liquid culture
Kent Garcia, Chester Jhae Garcia, Reynante Bustillos, Rich Milton DulaySalt stress, its impacts on plants and the strategies plants are employing against it: A review
Zeenat Mushtaq, Shahla Faizan, Basit GulzarImpact of oxidizing, reducing, and stabilizing agents on the inhibitory properties of Cyamopsis tetragonoloba trypsin inhibitor
Preeti Patidar, Mahima Golani, Sumati Hajela, Krishnan HajelaIdentification of highest L-Methioninase enzyme producers among soil microbial isolates, with potential antioxidant and anticancer properties
D. Kavya, Varalakshmi Kilingar NadumaneAstaxanthin: An algae-based natural compound with a potential role in human health-promoting effect: An updated comprehensive review
Jinu Medhi, Mohan Chandra KalitaLinalool protects hippocampal CA1 neurons and improves functional outcomes following experimental ischemia/reperfusion in rats
Vishal Airao, Prakruti Buch, Tejas Sharma, Devendra Vaishnav, Sachin ParmarModification of the time of incubation in colorimetric method for accurate determination of the total antioxidants capacity using 2,2-diphenyl-1-picrylhydrazyl stable free radical
Abhipsa Bal, Samar Gourav Pati, Falguni Panda, Biswaranjan PaitalHR-LC-MS based profiling of phytochemicals from methanol extracts of leaves and bark of Myristica dactyloides Gaertn. from Western Ghats of Karnataka, India
Kuppuru Mallikarjunaiah Marulasiddaswamy, Bettadapura Rameshgowda Nuthan,, Channarayapatna-Ramesh Sunilkumar, Shrisha Naik Bajpe,, Kigga Kaadappa Sampath Kumara, Shailasree Sekhar, Kukkundoor Ramachandra KiniPreclinical evaluation of anticataract activity of Mentha spicata leaves on isolated goat lens by an in vitro model
Shreya Mohandas, Saahiba Thaleshwari, Myrene Roselyn DsouzaGreen synthesis, characterizations, and in vitro biological evaluation of Cu (II) complexes of quercetin with N ^ N ligands
Tanu Srivastava, Sunil Kumar Mishra, Om Prakash TiwariOptimization of extraction conditions of phytochemical compounds in “Xiem” banana peel powder using response surface methodology
Ngo Van Tai, Mai Nhat Linh, Nguyen Minh ThuyAntioxidative, antiproliferative, and apoptosis effect of Coleus tuberosus flesh and peel ethanol extracts on cervical cancer cell lines
Mutiara Nugraheni, Windarwati Windarwati, Badraningsih LastariwatiComparative study of hydroalcoholic extracts of Bryophyllum pinnatum and Macrotyloma uniflorum for their antioxidant, antiurolithiatic, and wound healing potential
Chetna Faujdar, PriyadarshiniQualitative and quantitative analysis of Precocene II, estimation of enzymatic, nonenzymatic antioxidant, and cytotoxic potentials of methyl jasmonate-elicited shoot culture of Ageratum conyzoides Linn.
Selvaraj Vasantharani, Ramaraj Thirugnanasampandan, Gunasekaran BhuvaneswariSuppression of the RAGE gene expression in RAW 264.7 murine leukemia cell line by ethyl acetate extract of Mikania micrantha (L.) Kunth.
Alex Zohmachhuana, Malsawmdawngliana Tlaisun, Vabeiryureilai Mathipi, Lalrinzuali Khawlhring, Joyce Sudandara PriyaA review on fish peptides isolated from fish waste with their potent bioactivities
Ayusman Behera, Rajashree Das, Pranati Patnaik, Jyotirmaya Mohanty, Gargee MohantyQuantification of phytochemicals and in vitro antioxidant activities from various parts of Euphorbia neriifolia Linn.
Priya Chaudhary, Pracheta JanmedaInfluence of soaking and germination treatments on the nutritional, anti-nutritional, and bioactive composition of pigeon pea (Cajanus cajan L.)
Qurat Ul Eain Hyder Rizvi, Krishan Kumar, Naseer Ahmed, Ajar Nath Yadav, Divya Chauhan, Priyanka Thakur, Sumaira Jan, Imran SheikhImpact of diverse processing treatments on nutritional and anti-nutritional characteristics of soybean (Glycine max L.)
Priyanka Thakur, Krishan Kumar, Naseer Ahmed, Ajar Nath Yadav, Sunil Kumar, Qurat Ul Eain Hyder Rizvi, Divya Chauhan, Sumaira JanCathelicidin-HR from Hoplobatrachus rugulosus: an antioxidant peptide that performs a protective effect against UV/H2O2 -induced DNA damage
Piyachat Wiriyaampaiwong, Chutima Karnmongkol, Arpaporn Punpad, Nattapong Srisamoot, Wutti Rattanavichai, Alongkod Tanomtong, Sakda Daduang,, Sompong Klaynongsruang,, Anupong Tankrathok,Woodfordia fruticosa (Linn.) Kurz’s fungal endophyte Mucor souzae’s secondary metabolites, kaempferol and quercetin, bestow biological activities
Kavyashree Doreswamy, Priyanka Shenoy, Sneha Bhaskar, Ramachandra K. Kini, Shailasree SekharCharacterization of the crude extract of Portulaca oleracea and the determination of the polyphenol oxidase kinetics in the presence of Cu and Zn
Omar Mohammad Atrooz, Shada Zaher Al-MaitahEffect of diverse fermentation treatments on nutritional composition, bioactive components, and anti-nutritional factors of finger millet (Eleusine coracana L.)
Sumaira Jan, Krishan Kumar, Ajar Nath Yadav, Naseer Ahmed, Priyanka Thakur, Divya Chauhan, Qurat-Ul-Eain Hyder Rizvi, Harcharan Singh DhaliwalOptimization of active antioxidative defatted Canarium indicum L. (Canary) protein hydrolysate production
Cintya Nurul Apsari,, Ilma Nugrahani, Sukrasno, Tutus GusdinarElemental, nutritional, and phytochemical profiling and antioxidant activity of Cordia obliqua Willd. (Clammy Cherry): An important underutilized forest tree of East India
Mamta Naik#,, Shashikanta Behera#,,, Sadhni Induar, Swaraj K. Babu, Pradeep K. NaikEffects of enzymatic hydrolysis on the antioxidant activity of protein hydrolysate derived from the larvae of black soldier fly (Hermetia illucens L.)
Muhammad Yusuf Abduh,, Diah Ayu Prawitasari,, Ula Aulia Fitrian,, Mochamad Firmansyah,Evaluation of functional characteristics of roselle seed and its use as a partial replacement of wheat flour in soft bread making
Nguyen Minh Thuy, Nguyen Bao Tram, Dinh Gia Cuong, Huynh Khanh Duy, Ly Thanh An, Vo Quoc Tien, Tran Ngoc Giau, Ngo Van TaiTotal phenolic, flavonoid contents, and antioxidant activity of three selected Portulaca grandiflora mutants in MV8 generation as a result of recurrent irradiation technique
Waras Nurcholis,, Syarifah Iis Aisyah, Regina Agritena Mayrischa Saraswati, Yoshua Shandy YudhaInsights into the impact of spermidine in reducing salinity stress in Gerbera jamesonii
Javeria Uzma, Sai Krishna Talla, Praveen MamidalaEffect of combined NPK fertilizer on polyphenol contents and antioxidant activity in methanol extract of Curcuma xanthorhiza
Minarni Minarni, Rayandra Asyhar, Amira Amandanisa, Sintya Ainun, Yoshua Shandy Yudha, I Made Artika,, Waras Nurcholis,Dehydration kinetics of green banana slices, characterization of optimized product based on physicochemical, nutritional, optical, and sensory attributes
Ram Kaduji Gadhave, Ravneet Kaur, Rahul Das, Kamlesh PrasadAssessment of morpho-agronomic and yield attributes in gamma-irradiated mutants of Kalanamak rice (Oryza sativa L.)
Tanmai Mishra, Anjali Singh, Virendra Kumar Madhukar, Ashutosh Kumar Verma, Shambhavi Mishra, Rajveer Singh ChauhanMetabolic profile, bioactivities, and variations in chemical constituents of essential oils of twenty mango ginger (Curcuma amada) accessions
Jyotirmayee Lenka, Snehalata Khuntia, Basudeba Kar, Suprava SahooPhenolic compounds and in vitro antioxidant activity of spray-dried and freeze-dried aqueous extracts of sea cucumber (Holothuria tubulosa)
Fadna Aatab, Fatima Bellali, Fatima Zahra Aboudamia, Ahmed Errhif, Mariem KharroubiOptimization of pasteurization process of the ready-to-drink beverage from Hong Quan (Flacourtia jangomas) fruit by response surface methodology
Tan Duy Nguyen,, Tuyen Thi Xuan Vo,, Khang Nghia Tran,Increasing polyphenol antioxidant in Orthosiphon stamineus Benth leaves with fermentation extraction by Saccharomyces cerevisiae ATCC-9763
Muhammad Aria Chandra, Khaswar Syamsu, Laksmi Ambarsari, Nurul Fatimah, Waras Nurcholis,Phytochemical composition and antiproliferative activity of Opuntia elatior Mill.: In vitro and in silico studies on breast cancer cell line MCF-7
Foram Patel, Khushali Upadhyay, Denni Mammen, Elizabeth Robin, A.V. Ramachandran, Darshee BaxiBioactive properties of the extracts of peels, pomace, seeds, and essential oils of Citrus limon and Citrus aurantifolia
Folasade Oluwatobi, Olakunle Afolabi, Pius Okiki, Funmilayo Adeniyi, Oghenerobor AkporHigh resolution-liquid chromatograph mass spectrometer characterization of bioactive compounds in pineapple wastes: Valorization of antioxidant and enzymatic activity
Suman Polaki, Sourav Nayak, K. Sampad Kumar, Rabi Prasad BRecent important insight into nutraceuticals potential of pigmented rice cultivars: A promising ingredient for future food
Le Thi Kim Loan, Bui The Vinh, Ngo Van TaiElucidation of antioxidant compounds recovery capacity from “Cam” purple rice bran by different sustainable extraction techniques
Le Thi Kim Loan, Bui The Vinh, Ngo Van TaiSecondary metabolite profiles, antimicrobial and antioxidant activities of callus, and leaves extract of Piper sarmentosum Roxb.
Junairiah Junairiah, Listijani Suhargo, Tri Nurhariyati, Nabilah Istighfari ZuraidassanaazAssessment of in vitro antioxidant properties and anticancer potential of Cucumis pubescens Willd. a medicinal fruit, utilizing human lung cancer cell line (A549)
T. Sundari, R. Kavitha, B. Mythili Gnanamangai, S. SaranyaExploring Bougainvillea glabra flowers: a promising source of natural antimicrobial and anticancer agents
Wanchat Sirisarn, Auemphon Mordmuang, Kankamol Kerdkumthong, Sompop Saeheng,,The effectiveness of the use of antioxidant formulations in the storage of fat from the Pacific sardines Sardinops melanostictus
Oksana V. Tabakaeva, Lidia V. Shulgina,, Mouhamad Alrajab, Anton V. Tabakaev, Pavel A. Shinkaruk, Varvara D. StepochkinaEvaluation and characterization of endophytic bacteria from Capparis decidua (Forssk.) Edgew. for their antifungal and antioxidant activities
Sudesh Kumari, Prity Gulia, Pooja Choudhary, Ritu Pasrija, Mehak Dangi, Anil Kumar ChhillarSustainable improvement of nutrition quality and biological activity from cassava residue and okara through solid-state fermentation by Pleurotus citrinopileatus mycelium
Hang Nguyen Thi Bich, Cuong Chi Doan, Uyen Nguyen Khanh Phan, Khanh Trang Vu Le, Thang Duc Bui, Munehiro Tanaka, Minh Van Vo