Reference
1. Magnuson BA, Burdock GA, Doull J, Kroes RM, Marsh GM, Pariza MW, Spencer PS, Waddell WJ, Walker R, Williams GM. Aspartame: a safety elevation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol. 2007; 37:629-727.
2. Rencuzogullari E, Tuylu BA, Topaktas M, Ila HB, Kayraldiz A, Arslan M, Diler SB. Genotoxicity of aspartame. Drug Chem Toxicol. 2004; 27:257–268.
3. Oppermann JA. Aspartame metabolism in animals. In: Stegink LD, Filer LJ (ed). Aspartame, physiology and biochemistry. Marcel Dekker Inc, New York; 1984, pp 141-159.
4. Stegink LD. Aspartame metabolism in humans: acute dosing studies. In: Stegink L, Filer L (ed) Aspartame: Physiology and biochemistry. Marcel Dekker, New York; 1984, pp 509-553.
5. Trocho C, Pardo R, Rafecas I, Virgili J, Remesar X, Fernandez- Lopez JA, Alemany M. Formaldehyde derived from dietary aspartame binds to tissue components in vivo. Life Sci. 1998; 63:337-349.
6. Woodrow C. Monte and methanol. J Appl Nutr. 1984; 36:1-15.
7. Maher TJ and Wurtman RJ. Possible neurologic effects of aspartame, a widely used food additive. Environ Health Perspect. 1987; 75:53-57.
8. Dailey JW, Lasley SM, Burger RL, Bettendorf AF, Mishra PK and Jobe PC. Amino acids, monoamines and audiogenic seizures in genetically epilepsy-prone rats: effects of aspartame. Epilepsy Res. 1991; 8:122-133.
9. Diomede L, Romano M, Guiso G, Caccia S, Nava S, Salmona M. Interspecies and interstrain studies on the increased susceptibility to metrazol-induced convulsions in animals given aspartame. Food Chem Toxicol. 1991; 29:101-106.
10. Humphries P, Pretorius E, Naude H. Direct and indirect cellular effects of aspartame on the brain. Eur J Clin Nutr. 2008; 62:451-462.
11. Kruse JA. Methanol poisoning. Intensive Care Med. 1992; 18:391-397.
12. Davoli E. Serum methanol concentrations in rats and in men after a single dose of aspartame. Food Chem Toxicol. 1986; 24:187-189.
13. Poli G. Liver damage due to free radicals. Br Med Bull. 1993; 49:604-609.
14. Parthasarathy JN, Ramasundaram SK, Sundaramahalingam M, Pathinasamy SD. Methanol induced oxidative stress in rat lymphoid organs. J Occup Health. 2006; 48:20-27.
15. Castro GD, Costantini MH, Delgado de layno AM, Castro A. Rat liver microsomal and nuclear activation of methanol to hydroxyl methyl free radicals. Toxicol Lett. 2002; 129:227-236.
16. Ishak KG, Zimmerman HJ, Ray MB. Alcoholic liver disease: pathologic, pathogenetic and clinical aspects. Alcohol Clin Exp Res. 1991; 15:45-66.
17. Fernandez-Checa JC, Kaplowitz N, Colell A, Garcia-Ruiz C. Oxidative stress and alcoholic liver disease. Alcohol Health Res World. 1997; 21:321-324.
18. Betteridge DJ. What is oxidative stress. Metabolism. 2000; 49:3-4.
19. Lopaczyski W, Zeisel SH. Antioxidants, programmed cell death, and cancer. Nutr Res. 2001; 21:295-307.
20. Karim A, Burns T. Metabolism and pharmacokinetics of radio labeled aspartame in normal subjects. In: Tschanz C, Butchko HH, Stargel WW, Kotsonis FN(ed) The clinical evaluation of a food additive. Assessment of aspartame. Boca Raton, New York, London, Tokyo: CRC; 1996, pp 57-66.
21. Stegink LD, Filer LJ. Effects of aspartame ingestion on plasma aspartate, phenylalanine and methanol concentrations in normal adults. In: Tschanz C, Butchko HH, Stargel WW, Kotsonis FN (ed) The clinical evaluation of a food additive. Assessment of aspartame. Boca Raton, New York, London, Tokyo: CRC Press; 1996, pp 67-86.
22. Trefz FK, Bickel H. Tolerance in PKU heterozygotes. In: Tschanz C, Butchko HH, Starge, WW, Kotsonis FN (ed) The clinical evaluation of a food additive. Assessment of aspartame; 1996, pp. 149-160.
23. Stegink LD. The aspartame story: a model for the clinical testing of a food additive. Am J Clin Nutr. 1987; 46:204-215.
24. Cheese-man KH. Mechanisms and effects of lipid peroxidation. Mol Aspects Med. 1993; 14:191-197.
25. Mylonas C and Kouretas D. Lipid peroxidation and tissue damage. In vivo. 1999; 13:295-309.
26. Bergendi L, Benes L, Durackova Z, Ferencik. Chemistry, Physiology and Pathology of free radicals. Life Sci. 1999; 65:1865-1874.
27. Zeyuan D, Bingyin T, Xiaolin L, Jinming H, Yifeng C. Effect of green tea and black tea on the blood glucose, the blood triglycerides and antioxidation in aged rats. J Agric Food Chem. 1998; 46:3875-3878.
28. Zararsiz I, Sarsilmaz M, Tas U, Kus I, Meydan S, Ozan E. Protective effect of melatonin against formaldehyde- induced kidney damage in rats. Toxicol Ind Health. 2007; 23:573-579.
29. Winterbourn CC. Concerted antioxidant activity of glutathione and superoxide dismutase. In: Packer L, Fuchs J (ed) Biothiols in health and disease. Marcel Dekker Inc, New York; 1995, pp 117-34.
30. Abuja PM, Albertini R. Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins. Clin Chim Acta. 2001; 306:1-17.
31. Singh P, Mann KA, Mangat HK, Kaur G. Prolonged glutamate excitotoxicity: Effects of mitochondrial antioxidants and antioxidant enzymes. Mol Cell Biochem. 2003; 243:139-145.
32. Hashimoto K, Takasaki W, Yamoto T, Manabe SI, Tsuda S. Effect of glutathione (GSH) depletion on DNA damage and blood chemistry in aged and young rats. J Toxicol Sci. 2008; 33:421-429.
33. Jones DJ, Eklow L, Thor H, Orrenius S. Metabolism of hydrogen peroxide in isolated hepatocytes: relative contribution of catalase and glutathione peroxidase in decomposition of endogenous generated H2O2. Arch Biochem Biophys. 1981; 210:505-516.
34. Meister A, Anderson S. Glutathione . Ann Rev Biochem. 1983; 52: 711-760.
35. Oyama Y, Sakai H, Arata T, Okano Y, Akaike N, Sakai K, Noda K. Cytotoxic effects of methanol, formaldehyde and formate on dissociated rat thymocytes: a possibility of aspartame toxicity. Cell Biol Toxicol. 2002; 18:43-50.
36. Pankow D, Jagielki S. Effect of methanol on modifications of hepatic glutathione concentration on the metabolism of dichloromethane to carbon monoxide in rats. Hum Exp Toxicol. 1993; 12:227-231.
37. Sogut, S, Songur A, Ozen OA, Ozyurt H, Sarsilmaz M. Does the sub acute (4 week) exposure to formaldehyde inhalation lead to oxidant/antioxidant imbalance in rat liver. Eur J Gen Med. 2004 1:26-32.
38. Skrzydlewska E. Toxicological and metabolic consequences of methanol poisoning. Toxicol Mechan Methods. 2003; 13:277-293.
39. Prabhakar R, Vreven T, Morokuma K, Musaev DG. Elucidation of the mechanism of selenoprotein glutathione peroxidase (GPx) catalyzed hydrogen peroxide reduction by two glutathione molecules: a density functional study. Biochemistry. 2005; 44:11864-11871.
40. Reiter RJ. Melatonin: lowering the high price of free radicals. News Physiol Sci. 2000; 15:246-250.
41. Morena I, Pichardo S, Jos A, Gomez-Amores L, Mate A, Vasquez CM, Camean AM. Antioxidant enzyme activities and lipid peroxidation in liver and kidney of rats exposed to Microcystin LR administered intraperitoneally. Toxicon. 2005; 45:395-402.
42. Fridovich I. Superoxide dismutase. Ann Rev Biochem. 1975; 44:147-159.
43. Kono Y, Fridorich I. Superoxide radical inhibits catalase. J Biol Chem. 1982; 257:5751-5754.
44. Pigeolet E, Corbisler P, Houbion A. Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals. Mech Ageing Dev. 1990; 51:283-97.
45. Skrzydlewska E, Elas M, Farbiszewski R, Roszkowska A. Effect of methanol intoxication on free-radical induced protein oxidation. J Appl Toxicol. 2000; 20:239-243.
46. Gulec M, Gurel A, Armutcu F. Vitamin E protects against oxidative damage caused by a formaldehyde in the liver and plasma of rats. Mol Cell Biochem. 2006; 290:61-67.
47. Chang JR, Xu DQ. Effects of formaldehyde on the activity of superoxide dismutase and glutathione peroxidase and the concentration of malondialdehyde. Wei Sheng Yan Jiu Sept. 2006; 35:653- 655.
48. Tuna G, Erkmen GK, Dalmizrak O, Dogan A, Ogus IH, Ozer N. Inhibition characteristics of hypericin on rat small intestine glutathione- S- transferase. Chem Biol Interact. 2010; 188:59-65.
49. Mourad IM. Effect of aspartame on some oxidative stress parameters in liver and kidney of rats. Afr J Pharm Pharmacol. 2011; 5:678-682.
50. Giannini EG, Testa R, Savarino V. Liver enzyme alteration: a guide for clinicians. CMAJ. 2005; 172:367-379.
51. Lee DH, Blomhoff R, Jacobs DR. Serum gamma glutamyl transferase a marker of oxidative stress. Free Radical Res. 2004; 38:535-539.