Chilli leaf curl virus (ChiLCV) belongs to the genus begomovirus (Family Geminiviridae), can infect chilli and many other crops. The coat protein (CP) of ChiLCV binds with the genomic viral ssDNA and shuttles it in and out of the cell nucleus. The distinct role of CP genes is viral capsid formation and transmission by whitefly. In this study, the interaction of CP with selected plant flavonoids and chemical compounds is explained. The CP of ChiLCV were selected from India, Pakistan, Oman, and Sri Lanka. This study focuses on understanding the structure of CPs from different regions and molecular docking studies to inhibit ssDNA binding for transportation of CP AV1 of ChiLCV. Molecular docking is carried between proteins and selected flavonoids and chemical compounds. Flavonoids show potent inhibition at the binding site of AV1. The outcomes obtained from this study direct that flavonoids' performance promises as compare with other chemical compounds. This information might be interesting to study plant defense mechanisms based on the plants' unique compounds.
Jeyaraj G, Mohideen HS, Geetanjali AS. Ab-initio modelingmodelling and docking evaluation of geographically derived coat proteins of chilli leaf curl virus with flavonoids and chemical compounds. J Appl Biol Biotech, 2021;9(S1):40-51.
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