Research Article | Volume: 4, Issue: 5, Sep-Oct, 2016

Effects of Vitex doniana leaf extract on aluminium-induced toxicity in male albino Wistar rats

O. E. Yakubu O. F. C. Nwodo C. Imo M. Abdulrahaman L. B. Uyeh   

Open Access   

Published:  Oct 23, 2016

DOI: 10.7324/JABB.2016.40506

This study was conducted to determine the effect of ethanolic leaf extract of Vitex doniana on the toxicity induced by aluminium chloride in male Wistar albino rats. A total of 15 male albino rats were used for the study and toxicity was induced using 100mg/kg body weight (bw) AlCl3. They were grouped into three (five rats in each group): normal control, AlCl3 control and AlCl3 + 100mg Vitex doniana respectively. The normal control group was fed with standard rat chow only, while the AlCl3 control group was orally administered 100mg/kgbw AlCl3, and the AlCl3 + V.D group was orally administered 100mg/kgbw extract following administration of AlCl3. The study was conducted for 7 days after which the effect of the extract was assessed following the animal sacrifice. Oral dose of 100mg/kg bw extract of Vitex doniana did not show any significant change in TBARS level of liver and testes in the experimental groups, while the AST, ALT and ALP levels in AlCl3 control and AlCl3 + 100mg Vitex doniana showed significant increase (p<0.05) and non-significant increase (except ALT which increased significantly) with control group respectively. The PCV and Hb levels did not show any significant (p>0.05) change from the control group, while there was no significant difference in bilirubin level among the different experimental groups. More research should therefore be done on this study to further understand the usefulness of ethanolic leaf extract of Vitex doniana, and encourage its application in herbal medicine.

Keyword:     Vitex doniana Aluminum Chloride toxicity Albino rats ethanolic extract.


Yakubu, O. E., Nwodo, O. F. C., Abdulrahaman, M. and Uyeh, L. B. Effects of Vitex doniana leaf extract on aluminium-induced toxicity in male albino Wistar rats. J App Biol Biotech. 2016; 4 (05): 037-040. DOI: 10.7324/JABB.2016.40506

Copyright: Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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