Standardization of Prasaranyadi Kashayam – a classical Ayurvedic polyherbal formulation

Paras Sharma Prashant Kumar Dhakad   

Open Access   

Published:  Jul 18, 2024

DOI: 10.7324/JABB.2024.1715945317
Abstract

Prasarinyadi Kashayam is used to treat Vata illnesses and joint discomfort in Ayurvedic system of medicine. It is mostly used to alleviate musculoskeletal issues and joint pain. It has traditionally been used to treat cervical spondylosis, frozen shoulder, headaches, and lower back pain and stiffness related to lumbar spondylosis. The present work was aimed to develop the pharmacognostic parameters for the standardization and quality evaluation of the Prasaranyadi Kashayam. In house polyherebal formulation was prepared as per the previously prescribed method and physichochemical parameters were evaluated as per  standard protocol and showed loss on drying 99.31%, Total ash 4.911±0.120%, water soluble ash: 3.022, acid insoluble ash: 0.489. Total phenolic content was estimated with FC reagent and expressed as gallic acid equivalent (9.95 + 0.004 mg/g). High performance thin layer chromatography (HPTLC) fingerprint profiling was obtained, using Toluene: Ethyl Acetate: Formic acid (2.5: 2.0: 0.5) as mobile phase. The characterization parameters presented in this paper may serve as standard reference for quality control analysis of Prasaranyadi Kashayam.


Keyword:     Standardization HPTLC Finger printing Prasaranyadi Kashayam


Citation:

Sharma P, Dhakad PK. Standardization of Prasaranyadi Kashayam – a classical Ayurvedic polyherbal formulation. J App Biol Biotech. 2024. Online first. http://doi.org/10.7324/JABB.2024.1715945317

Copyright: Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

HTML Full Text
Reference

1. Balekundri, A., Mannur, V. Quality control of the traditional herbs and herbal products: a review. Futur J Pharm Sci 6, 67 (2020).
https://doi.org/10.1186/s43094-020-00091-5

2. Wang H, Chen Y, Wang L, Liu Q, Yang S and Wang C. Advancing herbal medicine: enhancing product quality and safety through robust quality control practices. Front. Pharmacol.2023; 14:1265178.
https://doi.org/10.3389/fphar.2023.1265178

3. Singh, S. K., Jha, S. K., Chaudhary, A., Yadava, R. D. S., & Rai, S. B. (2010). Quality control of herbal medicines by using spectroscopic techniques and multivariate statistical analysis. Pharmaceutical Biology, 48(2), 134-141.
https://doi.org/10.3109/13880200903059388

4. Hopkins AL. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 2008;4:682e90.
https://doi.org/10.1038/nchembio.118

5. Tripathi A, Bankaitis VA. Molecular docking: from lock and key to combination lock. J Mol Med Clin Appl 2017;2(10):10.
https://doi.org/10.16966/2575-0305.106

6. Nisteshwar K, Vidyanath R. Sahasrayogam: A popular book on Keraliya tradition of Ayurvedic Treatment. Banaras Ayurveda Series No. 20. 4th Ed, 2017.

7. Anonymous. Indian Herbal Pharmacopoeia. Publisher: Indian Drug Manufacturers" Association. 2002.

8. Anonymous. The Ayurvedic Pharmacopoeia of India. Publisher: Pharmacopoeia commission for indian medicine & homoeopathy, Ghaziabad. Vol IX, 2016.

9. Molole, G.J., Gure, A. & Abdissa, N. Determination of total phenolic content and antioxidant activity of Commiphora mollis (Oliv.) Engl. resin. BMC Chemistry 16, 48 (2022).
https://doi.org/10.1186/s13065-022-00841-x

Article Metrics
89 Views 0 Downloads 89 Total

Year

Month

Related Search

By author names