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Volume: 2, Issue: 5, Sep-Oct, 2014
Meta-analysis of variant rs 7903146 of TCF7L2 gene with secondary complications of Type 2 Diabetes Mellitus
Kanhaiya Singh, NK Agrawal, SK Gupta, Kiran Singh
Persistent hyperglycemia in patients with Type 2 diabetes mellitus is driving force for developing secondary complications like neuropathy, retinopathy, nephropathy, cardiomyopathy and wound healing impairment in them. Other genetic risk factor includes variants of transcription factor 7-like 2 (TCF7L2) gene, which have been shown to be associated with these several secondary complications individually. The present study represents a systematic review and Meta analysis using electronic databases like PubMed, OMIM, ISI web of science and Embase to see the role of rs7903146 C>T variant of the TCF7L2 gene with secondary complications of T2DM. Data was collected using literature-based searching to perform a Meta analysis to pool the odds ratio (OR). This Meta analysis comprised of a total of 2060 cases with secondary complication of T2DM and 3049 age matched controls. Publication bias and study-between heterogeneity were also evaluated. The present Meta analysis of included studies showed a highly significant association of risk genotype TT with development of secondary complications in T2DM.
Keywords: Transcription factor 7-like 2 (TCF7L2), Polymorphism, T2DM, secondary complications, Meta analysis.