Home >Archive

Volume: 2, Issue: 5, Sep-Oct, 2014

Sep-Oct, 2014

DOI: 10.7324/JABB.2014.2501

Research Article

Meta-analysis of variant rs 7903146 of TCF7L2 gene with secondary complications of Type 2 Diabetes Mellitus

Kanhaiya Singh, NK Agrawal, SK Gupta, Kiran Singh

  Author Affiliations


Abstract

Persistent hyperglycemia in patients with Type 2 diabetes mellitus is driving force for developing secondary complications like neuropathy, retinopathy, nephropathy, cardiomyopathy and wound healing impairment in them. Other genetic risk factor includes variants of transcription factor 7-like 2 (TCF7L2) gene, which have been shown to be associated with these several secondary complications individually. The present study represents a systematic review and Meta analysis using electronic databases like PubMed, OMIM, ISI web of science and Embase to see the role of rs7903146 C>T variant of the TCF7L2 gene with secondary complications of T2DM. Data was collected using literature-based searching to perform a Meta analysis to pool the odds ratio (OR). This Meta analysis comprised of a total of 2060 cases with secondary complication of T2DM and 3049 age matched controls. Publication bias and study-between heterogeneity were also evaluated. The present Meta analysis of included studies showed a highly significant association of risk genotype TT with development of secondary complications in T2DM.

Keywords: Transcription factor 7-like 2 (TCF7L2), Polymorphism, T2DM, secondary complications, Meta analysis.


Citation: Kanhaiya Singh, NK Agrawal, SK Gupta, Kiran Singh. Meta analysis of variant rs 7903146 of TCF7L2 with secondary complications of Type 2 Diabetes Mellitus. J App Biol Biotech. 2014; 2 (05): 001-005. DOI: 10.7324/JABB.2014.2501


Copyright: Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

References

1. Singh K, Agrawal NK, Gupta SK, Singh K. A functional SNP-1562C>T in the matrix metalloproteinases-9 promoter is associated with type 2 diabetes and diabetic foot ulcers. Int J Lower Extrem Wounds. 2013; 12(3): 199-204

2. World Health Organization. Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications: Report of a WHO Consultation (WHO/NCD/NCS/99.2). Geneva, Switzerland: World Health Organization; 1999.

3. Ali O. Genetics of type 2 diabetes. World J Diabetes. 2013; 4(4): 114–123.

4. Chauhan G, Spurgeon CJ, Tabassum R et al. Impact of Common Variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the Risk of Type 2 Diabetes in 5,164 Indians. Diabetes. 2010; 59(8): 2068–2074

5. Singh K, Agrawal NK, Gupta SK, Mohan G, Chaturvedi S and Singh K. Differential expression of Matrix metalloproteinase-9 gene in wounds of T2DM cases with susceptible -1562C>T genotypes and wound severity. Int J Lower Extrem Wounds. 2014; 13(2): 94-102.

6. Laeremans H, Rensen SS, Harry CJ et al.: Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts. Cardiovascular Research. 2010; 87: 514-523.

7. Cheon SS, Wei Q, Gurung A et al.: Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. FASEB Journal. 2006; 20: 692–701.

8. Prunier C, Hocevar BA, Howe PH et al.: Wnt signaling: physiology and pathology. Growth Factors. 2004; 22(3):141-150.

9. Hansson O, Zhou Y, Renstrom E et al.: Molecular function of TCF7L2: Consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes. Curr Diab Rep. 2010; 10(6): 444-451.

10. Lyssenko V, Lupi R, Marchetti P et al.: Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J. Clin. Invest. 2007; 117: 2155–2163.

11. Singh K, Agrawal NK, Gupta SK, Singh K. Association of Variant rs7903146 (C/T) Single nucleotide polymorphism of TCF7L2 gene with impairment in wound healing among north Indian Type 2 Diabetes population: A Case–Control Study. Int J Lower Extrem Wounds. 2013; 12(4): 310-315.

12. Buraczynska M, Swatowski A, Markowska-Gosik D et al.: Transcription factor 7-like 2 (TCF7L2) gene polymorphism and complication/comorbidity profile in type 2 diabetes patients. Diabetes research and clinical practice. 2011; 93: 390-395.

13. Ciccacci C, Fusco DD, Cacciotti L et al.: TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy. Acta Diabetol. 2012; DOI 10.1007/s00592-012-0418-x.

14. Zhang DL, Gu LJ, Liu L et al. Effect of Wnt signaling pathway on wound healing. Biochemical and Biophysical Research Communications. 2009; 378: 149–151.

15. Yi F, Brubaker PL, Jin T et al. TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3 beta. J Biol Chem. 2005; 280(2): 1457–1464.

16. Duggirala R, Blangero J, Almasy L: Linkage of Type 2 Diabetes Mellitus and of Age at Onset to a Genetic Location on Chromosome 10q in Mexican Americans. Am. J. Hum. Genet. 1999; 64: 1127–1140.

17. Grant SF, Thorleifsson G, Reynisdottir I et al. Variant of transcription factor 7-like 2 TCF7L2 gene confers risk of type 2 diabetes. Nature Genetics. 2006; 38: 320–323.

18. Cauchi S, El Achhab Y, Choquet H et al.: TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: A global meta-analysis. J Mol Med. 2007; 85: 777-782.

19. Bodhini D, Radha V, Dhar M et al.: The rs12255372 (G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians. Metabolism. 2007; 56: 1174-1178.

20. Chandak GR, Janipalli CS, Bhaskar S et al. Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia. 2007; 50: 63-67.

21. Rees SD, Bellary S, Britten AC et al. Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population. BMC Med Genet. 2008; 9:8.

22. Muendlein A, Saely CH, Geller-Rhomberg S et al. Single Nucleotide Polymorphisms of TCF7L2 Are Linked to Diabetic Coronary Atherosclerosis. PLoS ONE. 2011; 6(3): e17978.

23. Jin T and Liu L: The Wnt Signaling Pathway Effector TCF7L2 and Type 2 Diabetes Mellitus. Mol Endocrinol. 2008; 22(11): 2383–2392.

24. Saxena R, Gianniny L, Burtt NP et al. Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes. 2006; 55: 2890-2895.

25. Yi F, Brubaker PL, Jin T et al. TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta. J Biol Chem. 2005; 280: 1457-1464.

26. Cauchi S, Choquet H, Guti\érrez-Aguilar R et al.: Effects of TCF7L2 polymorphisms on obesity in European populations. Obesity 2008, 16(2):476-482.

27. Cauchi S and Froguel P. TCF7L2 Genetic Defect and Type 2 Diabetes. Current Diabetes Reports. 2008; 8:149–155.

28. Melzer D, Murray A, Hurst AJ et al. Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med. 2006; 4:34.

29. Sousa AGP, Marquezine GF, Lemos PA et al. TCF7L2 Polymorphism rs7903146 Is Associated with Coronary Artery Disease Severity and Mortality. PLoS ONE. 2009; 4(11): e7697.

Article Metrics

Similar Articles

Seed polymorphism in South Indian horsegram (Macrotyloma uniflorum (Lam.) Verdc.): A comprehensive study
Latha M,Suma A,Asha KI,NK Dwivedi,Mani S and Indiradevi A