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Volume: 7, Issue: 3, May-June, 2019
DOI: 10.7324/JABB.2019.70308

Research Article

Antibacterial potential of Caesalpinia bonducella extracts and their isolated phytoconstituents: in vitro and in silico analysis


S R Santosh Kumar1, Sudhesh L Shastri1, Venkatesh R2, K Pradeepa3, V Krishna1

  Author Affiliations


Abstract

The antimicrobial activity of Caesalpinia bonducella extracts such as CLC, CLE, CSC, and CSE and the phytoconstituents such as β-Sitosterol (LC3) isolated from CLC and methyl (4E)-5-{2-[(1E)-buta-1,3-dien-1-yl]- 4,6-dihydroxyphenyl} pent-4-enoate (SC2) isolated from CSC were evaluated on gram-positive and gram-negative bacteria. The extracts and isolated compounds were found to have moderate-to-significant bacterial inhibition. The significant activity was observed in the inhibition of Pseudomonas aeruginosa by CLC extract (16.10 ± 1.10 mm), whereas the isolated phytocomponent SC2 showed the highest inhibition (16.50 ± 0.58 mm). Further, the isolated compounds were subjected to molecular docking studies of the bacterial DNA Gyrase. The in silico study showed the docking energy of −6.4 and three hydrogen bonding. This in vitro and in silico analysis of extracts and isolated phytocomponents of C. bonducella helps to understand and evaluate the therapeutic efficacy to cure infectious diseases and also supports the traditional medicinal claim as an antibiotic.

Keywords:

Caesalpinia bonducella, Antimicrobial activity, Molecular docking study.



Citation: How to cite this article: Kumar SRS, Shastri SL, Venkatesh, Pradeepa K, Krishna V. Antibacterial potential of Caesalpinia bonducella extracts and their isolated phytoconstituents: In vitro and in silico analysis. J App Biol Biotech. 2019;7(03):41-46. DOI: 10.7324/JABB.2019.70308


Copyright: Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

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