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Volume: 7, Issue: 3, May-June, 2019
DOI: 10.7324/JABB.2019.70311

Research Article

Low dose and subchronic Aroclor 1254 induced histopathological changes in mice kidney

Jalpa Raja, Shweta Pathak, Rahul Kundu

  Author Affiliations


Present communication reports the low dose and subchronic duration-dependent histopathological changes after exposure to Aroclor 1254 in the kidney tissue of Swiss albino mice. Polychlorinated biphenyls (PCBs) like Aroclor 1254 congeners accumulate in tissues rich in lipids and remain inside for a long time, affecting the functionality of the cells in direct and indirect ways. The most commonly observed effects were skin ailments such as chloracne, rashes, and effects on kidney functions. Animal studies indicated that PCBs could affect the functionality of the kidney, thyroid, immune, and endocrine systems. Separate groups of mice were subjected to a daily oral dose of 0.1 mg/kg body weight (BW)/day and 1 mg/kg BW/day Aroclor 1254, dissolved in corn oil, for four subacute exposure durations (7, 14, 21, and 28 days). Control groups were received only the corn oil (vehicle). Results revealed mainly exposure duration-dependent histopathological lesions such as dilation of the tubular cells, fragmentation of cytoplasm and loss of nuclear materials, formation of large vacuoles inside the cells, and necrosis even at very low doses of Aroclor intoxication. The present study reports predominantly exposure duration-dependent histopathological effects of Aroclor 1254 in the kidney tissue of mice. The study suggested that the subacute exposure to low doses of Aroclor 1254 could cause significant irreparable structural deformities in the renal cells of the kidney tissue. Results also showed that renal tubular cells were more affected showing severe necrosis.


Polychlorinated biphenyls, Aroclor 1254, In vivo toxicity, Histopathology, Kidney, Mice.

Citation: Raja J, Pathak S, Kundu R. Low dose and subchronic Aroclor 1254 induced histopathological changes in mice kidney. J App Biol Biotech. 2019;7(03):59-62. DOI: 10.7324/JABB.2019.70311

Copyright: Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.


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