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Volume: 6, Issue: 6, Nov-Dec, 2018
DOI: 10.7324/JABB.2018.60614

Mini Review

Antimicrobial applications of sophorolipid from Candida bombicola: A promising alternative to conventional drugs

Victoria Akemi Itakura Silveira, Christiane Aparecida Urzedo Queiroz Freitas, Maria Antonia Pedrine Colabone Celligoi

  Author Affiliations


Abstract

Sophorolipids (SLs) are extracellular glycolipids, produced mainly by yeast Candida bombicola, composed of a disaccharide sophorose (O-β-D-glucopyranosyl-2-1-β-D-glucopyranose) linked by a glycosidic bound to the terminal or sub-terminal carbon of a fatty acid chain. Due to these structural characteristics, SLs have been reported with several applications, which are directly related to the predominance of their acidic and lactonic forms. SLs are the most promising and attractive biosurfactant, highlighting its antimicrobial action against Gram-positive and Gram-negative bacteria. The antimicrobial activities of SLs are due to the mechanism of changes or rupture in the cellular membrane, inducing the outpouring of their cytoplasmic contents, and the consequent death of the pathogen. This surfactant can be used as an alternative for the substitution of conventional drugs.

Keywords:

Biosurfactants, Candida bombicola, Antimicrobial agent, Membrane-damaging activity, Growth inhibition mechanism.



Citation: Silveira VAI, Freitas CAUQ, Celligoi MAPC. Antimicrobial applications of sophorolipid from Candida bombicola: A promising alternative to conventional drugs. J App Biol Biotech. 2018;6(06):87-90. DOI: 10.7324/JABB.2018.60614.


Copyright: Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.

References

1. Zhang H, Wu J, Guo X. Effects of antimicrobial and antioxidant activities of spice extracts on raw chicken meat quality. Food Science and Human Wellness, Beijing Academy of Food Sciences, 2016; 5(1): 39–48. https://doi.org/10.1016/j.fshw.2015.11.003

2. Chen M, Dong C, Penfold F, Thomas RK, Smyth TJP, Perfumo A, Marchant R, Banat IM, Stevenson P, Parry A, Tucker I, Campbell RA. Adsorption of sophorolipid biosurfactants on their own and mixed with sodium dodecyl benzene sulfonate, at the air/water interface. Langmuir, 2011; 27(14): 8854–8866. https://doi.org/10.1021/la201660n

3. Desai JD, Banat IM. Microbial production of surfactants and their commercial potential. Microbiology and molecular biology reviews : MMBR, 1997; 61(1): 47–64.

4. Cooper DG, Paddock DA. Production of a Biosurfactant from Torulopsis-Bombicola. Applied and Environmental Microbiology, 1984; 47(1): 173–176.

5. Asmer HJ, Lang S, Wagner F, Wray V. Microbial production, structure elucidation and bioconversion of sophorose lipids. Journal of the American Oil Chemists' Society, 1988; 65(9): 1460–1466. https://doi.org/10.1007/BF02898308

6. Morya VK, Park JH, Kim TJ, Jeon S, Kim EK. Production and characterization of low molecular weight sophorolipid under fed-batch culture. Bioresource Technology. Elsevier Ltd, 2013; 143: 282–288. https://doi.org/10.1007/s10529-010-0310-0

7. Paulino BN, Pessôa MG, Mano MCR, Molina G, Neri-Numa IA, Pastore GM. Current status in biotechnological production and applications of glycolipid biosurfactants. Applied Microbiology and Biotechnology, 2016; 100(24): 10265–10293. https://doi.org/10.1007/s00253-016-7980-z

8. Minucelli T, Ribeiro-Viana RM, Borsato D, Andrade G, Cely MVT, Oliveira MR, Baldo C, Celligoi MAPC. Sophorolipids Production by Candida bombicola ATCC 22214 and Its Potential Application in Soil Bioremediation, Waste and Biomass Valorization, 2017; 8(3): 743–753. https://doi.org/10.1007/s12649-016-9592-3

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