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Volume: 6, Issue: 6, Nov-Dec, 2018
DOI: 10.7324/JABB.2018.60614

Mini Review

Antimicrobial applications of sophorolipid from Candida bombicola: A promising alternative to conventional drugs

Victoria Akemi Itakura Silveira, Christiane Aparecida Urzedo Queiroz Freitas, Maria Antonia Pedrine Colabone Celligoi

  Author Affiliations


Sophorolipids (SLs) are extracellular glycolipids, produced mainly by yeast Candida bombicola, composed of a disaccharide sophorose (O-β-D-glucopyranosyl-2-1-β-D-glucopyranose) linked by a glycosidic bound to the terminal or sub-terminal carbon of a fatty acid chain. Due to these structural characteristics, SLs have been reported with several applications, which are directly related to the predominance of their acidic and lactonic forms. SLs are the most promising and attractive biosurfactant, highlighting its antimicrobial action against Gram-positive and Gram-negative bacteria. The antimicrobial activities of SLs are due to the mechanism of changes or rupture in the cellular membrane, inducing the outpouring of their cytoplasmic contents, and the consequent death of the pathogen. This surfactant can be used as an alternative for the substitution of conventional drugs.


Biosurfactants, Candida bombicola, Antimicrobial agent, Membrane-damaging activity, Growth inhibition mechanism.

Citation: Silveira VAI, Freitas CAUQ, Celligoi MAPC. Antimicrobial applications of sophorolipid from Candida bombicola: A promising alternative to conventional drugs. J App Biol Biotech. 2018;6(06):87-90. DOI: 10.7324/JABB.2018.60614.

Copyright: Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.


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