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Volume: 6, Issue: 6, Nov-Dec, 2018
DOI: 10.7324/JABB.2018.60607

Research Article

Aroclor 1254 induced oxidative stress and histopathological changes in mice liver

Jalpa Raja, Shweta Pathak, Rahul Kundu

  Author Affiliations


The toxicity of polychlorinated biphenyls in the living systems is associated with oxidative effects among others. In view of the involvement of antioxidant defense mechanisms in the detoxification of persistent organic pollutants, the present study was undertaken to assess the toxic effects of low dose (0.1 and 1 mg/kg/days) and long exposure (7, 14, 21, and 28 days) of Aroclor 1254 on glutathione content, specific activities of few antioxidant-related enzymes, and histopathological changes in the liver tissue of male mice. The obtained results indicated alterations in the enzyme activities of antioxidant-related defense mechanisms. The superoxide dismutase and glutathione peroxidase showed a significant increase in the specific activity, while, glutathione-S-transferase and reduced glutathione showed a significant duration dependent decreasing trend. Further, Aroclor 1254 induced oxidative stress might have caused the observed histopathological alterations, such as intravascular blood corpuscles accumulation, lipid granulomas, lipid deposition, cellular fibrosis, sinusoidal degeneration, and cellular aggregation in the liver tissue of mice. These pathophysiological changes in the liver tissue could be due to the generation of free radicals.


Polychlorinated biphenyls, Aroclor 1254, Antioxidant enzymes, Histopathology, Liver, Mice

Citation: Raja J, Pathak S, Kundu R. Aroclor 1254 induced oxidative stress and histopathological changes in mice liver. J App Biol Biotech. 2018;6(06):46-50. DOI: 10.7324/JABB.2018.60607

Copyright: Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.


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