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Volume: 6, Issue: 4, July-August, 2018
DOI: 10.7324/JABB.2018.60407

Research Article

Hepatoprotective activity of methanolic shoot extract of Bambusa bambos against carbon tetrachloride induce acute liver toxicity in Wistar rats

A. A. Shetti Suman Patil, H Joy Hoskeri, P Rajeev, Bhushan Kulkarni, Geetanjali R Kamble, Gurusiddhesh B Hiremath, Vishal Kalebar, S V Hiremath

  Author Affiliations


The young shoots of Bambusa bambos are used ayurvedic medicines in India. Young shoots content various chemical components such as cholin, betain, urease, cyanogenetic glucosides, oxalic acid, and benzoic acid. It has antiulcer, antifertility, anti-inflammatory, and antioxidant functions. In the present study, the hepatoprotective activity of methanolic shoot extract of B. bambos was tested against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Female Wistar rats were divided into five groups; Group I served as normal control. Groups II-VI were administered CCl4 mixed with olive oil 1:1 intraperitoneally (1 mL/kg body weight), after every 72 h for 16 days. Group II was CCl4 negative control. Groups IV and V received methanolic shoot extract mixed with olive oil, 200 mg and 400 mg/ kg body weight, respectively. Group III received silymarin 50 mg/kg body weight for 16 days orally once daily. Methanolic extract attenuated the increase in aspartate amino transaminase (AST) and alanine amino transaminase (ALT) as well as alkaline phosphatase (ALP) and total bilirubin that occur during liver injury after CCl4 injection. Outcome of the present study suggests that treatment with methanolic shoot extract of B. bambos- induced reduction in ALT, AST, ALP, and total bilirubin in rats indicating hepatoprotective potential of the extract.


Bambusa bambos, Hepatoprotective, Methanolic extract, Carbon tetrachloride.

Citation: Patil S, Shetti A, Hoskeri HJ, Rajeev P, Kulkarni B, Kamble GR, Hiremath GB, Kalebar V, Hiremath SV. Hepatoprotective activity of methanolic shoot extract of Bambusa bambos against carbon tetrachloride induce acute liver toxicity in Wistar rats. J App Biol Biotech. 2018;6(04):37-40. DOI: 10.7324/JABB.2018.60407

Copyright: Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.


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